From Harrisburg:

Take 1-83 South to North George Street exit. Proceed roughly 3 miles on North George Street; turn right onto West Philadelphia Street (at that light). Follow West Philadelphia Street two long blocks to Newberry Street; turn left at that light (at YMCA). Proceed one block to West Market Street; turn right at that light. 343 West Market Street is on the right between Penn Street and Newberry Street. Look for off-street parking lot.

From Baltimore:

Take 1-83 North to Exit 15 (left exit; South George Street/ Business Route 83). The road becomes South George Street. Follow roughly 3 miles to West College Avenue; turn left at that light. Follow West College Avenue .5 miles to Penn Street; turn right on Penn Street. Proceed .5 mile to West Market Street. Turn right at that light. 343 West Market Street is on the left between Penn Street and Newberry Street. Look for off-street parking lot.

From Gettysburg:

Take Route 30 East towards York. Take the West Market Street exit. Proceed 5 miles (past York Fair Grounds). 343 West Market Street is on the left between Penn Street and Newberry Street. Look for off-street parking lot.

From Lancaster:

Take Route 30 West to York. Proceed to North George Street; turn left at that light. Follow North George Street .25 mile to West Philadelphia Street; turn right at that light. Follow West Philadelphia Street .5 mile to North Penn Street; turn left at that light. Proceed one block to West Market Street; turn left at that light. 343 West Market Street is on the left between Penn Street and Newberry Street. Look for off-street parking lot.

Mapquest directions may be found here.